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Facial flushing burning

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Cutaneous flushing is a common presenting complaint in endocrine disorders. The pathophysiology of flushing involves changes in cutaneous blood flow triggered by multiple intrinsic factors that are either related to physiology or disease. Flushing can be divided into episodic or persistent causes. Episodic flushing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing results in a fixed facial erythema with telangiectasia and a cyanotic tinge owing to the large cutaneous blood vessels that contain slow-flowing deoxygenated blood. The differential diagnosis of cutaneous flushing in neuroendocrine disorders is limited, yet encompasses a broad spectrum of benign and malignant entities, including carcinoid syndrome, pheochromocytoma, Cushing syndrome, medullary thyroid cancer, and pancreatic neuroendocrine tumors. In this review, we provide a concise and up-to-date discussion on the differential diagnosis and approach of flushing in neuroendocrinology.
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Facial Flushing Caused by Mastocytosis and Other Conditions

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A flushing disorder: A case from the endocrine teaching clinics - Mayo Clinic

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What can cause flushed skin?

Flushed skin is often a visual sign of embarrassment, anxiety, or being too hot. However, frequent flushing can sometimes indicate an underlying medical condition. Flushed skin occurs when the hundreds of tiny blood vessels just beneath the skin dilate, or widen. When these blood vessels expand, they rapidly fill with more blood, which can make the skin appear red or pink.
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