Kurt T. Barnhart, Adriana Izquierdo, E. Scott Pretorius, David M. This study aimed to measure baseline dimensions of the undistended vagina of women of reproductive age. Seventy-seven MRI scans were performed on 28 women before gel application to establish baseline vaginal measurements.
Normal and abnormal vaginal microbiota
Baseline dimensions of the human vagina | Human Reproduction | Oxford Academic
The normal and abnormal vaginal microbiome are an ecosystem of up to species influenced by genetic, ethnic, environmental and behavioral factors. Cultural methods release only a small clinically unimportant spectrum. Lactobacilli are the most dominant and maintain a pH value between 3. They support a defense system against dysbiosis and infections to care for a healthy outer and inner genital tract, a balanced restitution after intercourse and normal pregnancy and childbirth. Bacterial vaginosis BV is the most frequent dysbiosis with a lack of lactobacilli and an overgrowth of anaerobic bacteria. Special Gardnerella vaginalis strains work together with Atopobium vaginae , Clostridiales and others, but also Lactobacillus iners in a vaginal polymicrobial biofilm, which is sexually transmitted and cannot be destroyed by the recommended antibiotics.
Differences in vaginal microbiome in African American women versus women of European ancestry
Metrics details. The bacterial community present in the female lower genital tract plays an important role in maternal and neonatal health. Imbalances in this microbiota have been associated with negative reproductive outcomes, such as spontaneous preterm birth sPTB , but the mechanisms underlying the association between a disturbed microbiota and sPTB remain poorly understood. An intrauterine infection ascending from the vagina is thought to be an important contributor to the onset of preterm labour. Microbiota profiles were created by PCR amplification and pyrosequencing of the cpn 60 universal target region.
The maintenance of a low pH in the vagina through the microbial production of lactic acid is known to be an important defense against infectious disease in reproductive age women. Previous studies have shown that this is largely accomplished through the metabolism of lactic acid bacteria, primarily species of Lactobacillus. Despite the importance of this defense mechanism to women's health, differences in the species composition of vaginal bacterial communities among women have not been well defined, nor is it known if and how these differences might be linked to differences in the risk of infection. In this study, we defined and compared the species composition of vaginal bacterial communities in Caucasian and black women in North America.