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Rat brain orgasm button

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A fundamental goal of neuroscience has always been to deduce the brain systems that underlie such basic drives as hunger, thirst and sex. En route to dinner, it received a pleasurable electric shock. The rat never showed up for mealtime, instead choosing to delight in the arousal. Better drugs are needed to suppress appetite and spark sexual desire. Undaunted, one clinician—who has trademarked the name Orgasmatron—ran a small, FDA-reviewed pilot trial to test the possibility of applying electric current to the spine to reverse sexual dysfunction. In Meloy reported that 10 of 11 women who stopped having or never had orgasms experienced sexual arousal with the temporary implant and, of that group, four had their ability to experience orgasm restored.
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The Functional Neuroanatomy of Pleasure and Happiness

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Subsequent research has failed to bring about this brave new world of boundless pleasure, but more recent findings have started to throw new light on the intriguing links between brain mechanisms of pleasure and happiness. We discuss these findings of the underlying neural mechanisms and functional neuroanatomy of pleasure in the brain. In particular we address how they may come to shed light on our understanding of the brain basis of happiness. We also address how understanding of the hedonic brain might help alleviate the suffering caused by the lack of pleasure, anhedonia, which is a central feature of affective disorders such as depression and chronic pain. Just over fifty years ago, psychologists James Olds and Peter Milner, working at McGill University in Canada, carried out their pioneering experiments which discovered that rats would repeatedly press levers to receive tiny jolts of current injected through electrodes implanted deep within their brains Olds and Milner, Especially when this brain stimulation was targeted at certain areas of the brain in the region of the septum and nucleus accumbens, the rats would repeatedly press the lever -- even up to times per hour Olds,
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A Sex Chip? Targeting the Brain's Pleasure Center with Electrodes

In the s, the psychologist B. Skinner devised the operant conditioning chamber, or "Skinner box," in which a lever press by an animal triggered either a reinforcing stimulus, such as delivery of food or water, or a punishing stimulus, such as a painful foot shock. Rats placed in a Skinner box will rapidly learn to press a lever for a food reward and to avoid pressing a lever that delivers the shock.
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Pleasure is mediated by well-developed mesocorticolimbic circuitry, and serves adaptive functions. In affective disorders anhedonia lack of pleasure or dysphoria negative affect can result from breakdowns of that hedonic system. Human neuroimaging studies indicate that surprisingly similar circuitry is activated by quite diverse pleasures, suggesting a common neural currency shared by all. Wanting for rewards is generated by a large and distributed brain system.
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